Ayellet Segrè, Ph.D. 

Principal Investigator

Assistant Professor of Ophthalmology, Harvard Medical School

Assistant Scientist, Ocular Genomics Institute, Massachusetts Eye and Ear (MEE)  

Co-Director, Biostatistics and Bioinformatics Core, MEE

Associate Member, Broad Institute of Harvard and MIT

Member of the Genotype-Tissue Expression (GTEx) Project Consortium

E-mail: ayellet_segre [at]

Jacqueline Ohmura, Ph.D.  

M.D. student at Harvard and MIT Health, Sciences and Technology (HST) MD program

Ph.D., Biological Engineering, MIT

B.S., Materials Engineering, Ohio State University, Columbus, OH

Co-mentored with Prof. Janey Wiggs, Mass. Eye and Ear, HMS

Jackie is using soft clustering analysis (non-negative matrix factorization) across genetic associations of known glaucoma loci with multiple endophenotypes of primary open angle glaucoma to identify pathogenic mechanisms and biological subtypes of glaucoma.

E-mail: Ohmura [at]

Katherine Duchinski

Ph.D. student in the Bioinformatics and Integrative Genomics (BIG) Program, Harvard Medical School

B.S., Biology and Data Sciences, College Of Charleston, Charleston, SC

Katherine is interested in integrating human genetics, functional genomics, and small molecule perturbational expression profiles to identify new drug repurposing opportunities for complex eye diseases, such as glaucoma and age-related macular degeneration.

E-mail: kduchinski [at]

Puja Mehta, M.Sc.


M.Sc., Bioinformatics, Northeastern University, Boston, MA

B.S., Biotechnology, Dayananda Sagar College of Engineering, Bengaluru, India

Puja is interested in using splicing QTLs in human retina to identify novel regulatory mechanisms that lead to age-related macular degeneration, and in integrating functional genomic and single cell data with GWAS to shed light on the causal mechanisms of eye disease.


Yuyang (Leo) Luo, Ph.D.


Ph.D., Biomedical Engineering, Rutgers University, Newark, NJ

M.Sc., Electronic and information Engineering, Stevens Institute of Technology, Hoboken, NJ

B.S., Electronic and information Engineering, Wuhan University of Science and Technology, China

Co-advised with Dr. Elizabeth Rossin and Prof. Janey Wiggs, Mass. Eye and Ear, HMS


Arushi Shrivastava, M.Sc.


M.Sc. in Bioinformatics Program at Boston University

B.S. in Biotechnology, JECRC University, Jaipur, Rajasthan, India

Songtao Xu, B.Sc.

MSc internship student

M.Sc. student in Biomedical Informatics Program, Harvard Medical School

B.A. in Computational Biology; Mathematical Sciences: Statistics, Colby College, Waterville, ME

Ashwathy Nair, M.Sc.


M.Sc., Bioinformatics, Northeastern University, Boston, MA

B.E in Biotechnology, SIES Graduate School of Technology, Mumbai, India

Alumni: Andrew Hamel, M.Sc. 

Bioinformatics Analyst, NBACC, Battelle National Biodefense Institute

M.Sc., Bioinformatics Program at Boston University

B.A., Biochemistry and Molecular Biology; Minor in Mathematics, The College of Wooster, Wooster, Ohio

Andrew is interested in combining functional genomics and systems biology with genome-wide association studies of complex diseases to gain new biological insights on the causes of disease. He is currently working on developing GWAS-eQTL enrichment methods to identify regulatory mechanisms, genes, and tissues that are implicated by genetic associations with complex eye diseases.

E-mail: andrew_hamel [at]

Alumni: John Rouhana, M.Sc.

Senior Research Associate at Gritstone Oncology

M.Sc., Bioinformatics, Northeastern University, Boston, MA

B.Sc., Premedical and Health Studies, MCPHS University, Boston, MA

Alumni: Jiali Wang, M.Sc., Ph.D.

Senior Principal Biostatistician at Novartis

Ph.D., Statistics, Australian National University, Australia

M.Sc.., Statistics, Australian National University, Australia

B.S., Mathematics, Capital Normal University, China