Data

The Primary Open Angle Glaucoma (POAG) GWAS excluding UK Biobank samples, used for polygenic risk score model training in manuscript: Zebardast et al., Penetrance and characteristics of Gln368Ter Myocilin variant in the UK Biobank,  under  revision  at  Ophthalmology  (Feb 2020), can be downloaded here:

“METAANALYSIS_POAG_EUROPEANS_IGGC_excludingUKBB.txt”. Summary statistics of POAG GWAS meta-analysis of European samples used in Stage 1 of the large cross-ancestry meta-analysis (https://pubmed.ncbi.nlm.nih.gov/33627673/), excluding UKBB samples (15,229 cases, 177,473 controls).

Chromosome positions are in human genome build 37.

Summary statistics of cross-ancestry POAG GWAS meta-analysis (European, African American East Asian) used in Stage 1 (https://pubmed.ncbi.nlm.nih.gov/33627673/), excluding UKBB samples, can be downloaded here: METAANALYSIS_POAG_COMBINED_ANCESTRIES_IGGC_excludingUKBB.txt.gz 

Chromosome positions are in human genome build 37.

POAG polygenic risk score (PRS) variant weights for all 1KG-imputed variants in the UK Biobank study (application 50211) using Lassosum (Mak et al. Genetic Epidemiology 2017, PMID: 28480976). The model was trained on POAG cases and controls from all ancestral groups in the UKBB, using the POAG cross-ancestry (European, African, Asian) GWAS meta-analysis summary statistics from Gharahkhani et al, Nat Comm 2021 (PMID: 33627673), excluding the UKBB samples from the meta-analysis (METAANALYSIS_POAG_COMBINED_ANCESTRIES_IGGC_excludingUKBB.txt.gz). 

Lassosum_PRS_variant_weights_POAG_CrossAncGWAS_Gharahkhani_2021_withchrX_1KG_EUR_LD_MEE_092022.csv

The last column "v$best.beta" contains the weights per variant. Chromosome positions are in human genome build 37.

Download README for more details on the training of the POAG PRS variant weights in the UK biobank.